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Journal of Biomolecular Screening
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FIZICS: Fluorescent Imaging Zone Identification System, A Novel Macro Imaging System

Stephen Skwish

P.O. Box 2000 Merck Research Laboratories Rahway, NJ 07065 USA stephen_skwish{at}merck.com

Francisco Asensio

Merck Sharp & Dohme, España, Madrid, Spain.

Gregking

Glenn Clarke

Gary Kath

Michael J. Salvatore

Claude Dufresne

Merck Research Laboratories, Rahway, NJ.

Constantly improving biological assay development continues to drive technological requirements. Recently, a specification was defined for capturingwhite light and fluorescent images of agar plates ranging in size from theNUNCOmnitray (96-well footprint, 128 · 85 mm) to the NUNC Bio Assay Dish (245 · 245 mm). An evaluation of commercially available products failed to identify any systemcapable of fluorescentmacroimaging with discretewavelength selection. To address the lack of a commercially available system, a customimaging systemwas designed and constructed. This systemprovides the same capabilities ofmany commercially available systemswith the added ability to fluorescently image up to a 245 · 245mmarea using wavelengths in the visible light spectrum.

Key Words: fluorescent imaging • macroimaging • image analysis • high-throughput screening

Journal of Biomolecular Screening, Vol. 9, No. 8, 663-670 (2004)
DOI: 10.1177/1087057104265289
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