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Journal of Biomolecular Screening
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HPLC Studio: A Novel Software Utility to Perform HPLC Chromatogram Comparison for Screening Purposes

J. B. García

juan_bautista_garcia{at}merck.com

José R. Tormo

Centro de Investigación Básica (CIBE), Merck, Sharp & Dohme España, Madrid, Spain.

A new tool, HPLC Studio, was developed for the comparison of high-performance liquid chromatography (HPLC) chromatograms from microbial extracts. The new utility makes it possible to create a virtual chromatogram by mixing up to 20 individual chromatograms. The virtual chromatogram is the first step in establishing a ranking of the microbial fermentation conditions based on either the area or diversity of HPLC peaks. The utility was used to maximize the diversity of secondary metabolites tested from a microorganism and therefore increase the chances of finding new lead compounds in a drug discovery program. (Journal of Biomolecular Screening 2003:305-315)

Key Words: HPLC Studio • high-performance liquid chromatography • software tools • virtual chromatogram

Journal of Biomolecular Screening, Vol. 8, No. 3, 305-315 (2003)
DOI: 10.1177/1087057103008003008
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