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Journal of Biomolecular Screening
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The Design and Development of an Integrated Natural Products Screening Database

Tom G. Holt

Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ

Claude Dufresne

Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ

Jerrold M. Liesch

Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ

Gary K. Mallow

Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ

We designed and developed NEXUS—a new natural products screening database and related suite of software applications-to utilize the spectacular increases in assay capacity of the modern high throughput screening (HTS) environment. NEXUS not only supports seamless integration with separate HTS systems, but supports user-customized integration with external laboratory automation, particularly sample preparation systems. Designed and developed based on a detailed process model for natural products drug discovery, NEXUS comprises two integrated parts: (1) a single schema of Oracle tables and callable procedures and functions, and (2) software "front-ends" to the database developed using Microsoft Excel and Oracle Discovery/2000. Many of the back-end processing functions were written in Programming Language/Structured Query Language (PL/SQL) to provide an Application Programmer's Interface, which allows end users to create custom applications with little input from information technology professionals.

Journal of Biomolecular Screening, Vol. 5, No. 6, 421-433 (2000)
DOI: 10.1177/108705710000500605
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