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Journal of Biomolecular Screening
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Microbiological High Throughput Screening: An Opportunity for the Lead Discovery Process

Marie-Helene Beydon

HTS, Aventis Pharma, Centre de Recherche de Vitry-Alfortville, Vitry sur Seine, France

Alain Fournier

Core Biotechnology, Aventis Pharma, Centre de Recherche de Vitry-Alfortville, Vitry sur Seine, France

Lionel Drugeault

Robotics Department, Aventis Pharma, Centre de Recherche de Vitry-Alfortville, Vitry sur Seine, France

Jerome Becquart

HTS, Aventis Pharma, Centre de Recherche de Vitry-Alfortville, Vitry sur Seine, France

Microbial HTS has been implemented at Rhone-Poulenc Rorer through the development of a dedicated robotic platform. This robot (Turbo) has been designed with the aim of fully integrating microbial HTS into the lead discovery processes. Innovative solutions have been found to reach high throughput as well as flexibility. This opens up new prospects for solid-phase microbial screening, taking advantage of the easy implementation and the very low costs of such screens. The different types of microbial screens done in our laboratory, as well as the throughputs and outputs obtained, are described. Some of the specific aspects of microbial HTS, as compared to biochemical and cell-based assays, are also discussed.

Journal of Biomolecular Screening, Vol. 5, No. 1, 13-21 (2000)
DOI: 10.1177/108705710000500105
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