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Journal of Biomolecular Screening
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The High Throughput Screening Infrastructure: The Right Tools for the Task

Mark Beggs

The Automation Partnership (Cambridge) Ltd., Royston, Herts, United Kingdom

Herman Blok

High Throughput Screening Department, Janssen Research Foundation, Beerse, Belgium

Annick Diels

High Throughput Screening Department, Janssen Research Foundation, Beerse, Belgium

HTS is a key component of pharmaceutical lead identification process. Over recent years, the pharmaceutical industry has experienced significant increases in the throughput capabilities of its HTS functions. In those companies where HTS has been effectively deployed, it is now possible to screen the entire corporate compound collection against a pharmacological target within a timescale of several weeks to a few months. This capability has been realized, not as a result of the purchase of any one particular piece of hardware, but rather through the development of a truly effective HTS infrastructure that matches the needs of the parent organization. Central to this is the need to understand how to effectively combine the use of the different types of hardware available to the HTS specialist. The use of both modular workstations and single-arm robotic systems have underpinned most HTS groups operations. Recent advances in the field of multiple-arm robotic systems and dedicated automation systems offer even further potential for increasing productivity. This article describes our experience with the use of a dedicated automation system for HTS applications.

Journal of Biomolecular Screening, Vol. 4, No. 3, 143-149 (1999)
DOI: 10.1177/108705719900400308
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Home page
 J Biomol ScreenHome page
M. Beggs, H. Blok, and J. Mertens
Stacker Modules Used in a High-Capacity Robotics System for High Throughput Screening Compound Replication
J Biomol Screen, December 1, 1999; 4(6): 373 - 379.
[Abstract] [PDF]