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Journal of Biomolecular Screening
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MultiPROBE nL Complements Drug Discovery Assay Miniaturization

Jennifer Driscoll

Small Molecule Chemistry, Amgen, Inc., Thousand Oaks, CA 91320

Ron Delmendo

Small Molecule Chemistry, Amgen, Inc., Thousand Oaks, CA 91320

Roeland Papen

Packard Instrument Co., Meriden, CT 06540

David Sawutz

Small Molecule Chemistry, Amgen, Inc., Thousand Oaks, CA 91320

The Packard MultiPROBE® nL is designed to enable the MultiPROBE Automated Liquid Handling System to aspirate and dispense nanoliter volumes. Several features add confidence to small volume transfers. A preview of nanoliter dispensing can be seen on a video camera monitor. In addition to the standard wash station, syringe and ultrasonic flushes can be run at the start of a program to prevent dirt or air obstructions. The MultiPROBE nL can transfer ionic, nonionic, and solutions containing organic solvents such as DMSO directly from master to assay plates and into high-density plate arrays. Additionally, the MultiPROBE nL increases the efficiency of generating dose response curves for secondary screening by eliminating a dilution step. IC50 values obtained after compound preparation with the instrument are consistent with those values previously determined using an MultiPROBE 208.

Journal of Biomolecular Screening, Vol. 3, No. 3, 237-239 (1998)
DOI: 10.1177/108705719800300311
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