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Journal of Biomolecular Screening
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Approaches to Automating the Dereplication of Bioactive Natural Products—The Key Step in High Throughput Screening of Bioactive Materials From Natural Sources

Derek J. Hook

NPS Pharmaceuticals, 420 Chipeta Way, Salt Lake City, UT 84108

Edward J. Pack

Bristol Myers Squibb, Department of Biomolecular Screening, Natural Products, 5 Research Parkway, Wallingford, CT 06492

Joseph J. Yacobucci

Bristol Myers Squibb, Department of Biomolecular Screening, Natural Products, 5 Research Parkway, Wallingford, CT 06492

Jeffrey Guss

Bristol Myers Squibb, Department of Biomolecular Screening, Natural Products, 5 Research Parkway, Wallingford, CT 06492

The rapid identification of the bioactive component(s) of natural product mixtures in high throughput screening programs has become a critical factor to ensure that this source of diverse chemotypes can compete effectively with chemical compound libraries and combinatorial synthetic efforts. The effective use of automated procedures and databases in the isolation, identification and biological profiling of bioactive compounds will be described. In addition, the potential of new technologies to enhance this process will be discussed as well as the possible reintroduction of TLC as a parallel dereplication method.

Journal of Biomolecular Screening, Vol. 2, No. 3, 145-152 (1997)
DOI: 10.1177/108705719700200304
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