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Journal of Biomolecular Screening
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Stem Cells in Drug Discovery, Tissue Engineering, and Regenerative Medicine: Emerging Opportunities and Challenges

Victor Sanjit Nirmalanandhan

University of Kansas Medical Center & Kansas Masonic Cancer Research Center, Department of Pharmacology Toxicology and Therapeutics, The Institute for Advancing Medical Innovation, Kansas City, Kansas

G. Sitta Sittampalam

University of Kansas Medical Center & Kansas Masonic Cancer Research Center, Department of Pharmacology Toxicology and Therapeutics, The Institute for Advancing Medical Innovation, Kansas City, Kansas, sitta{at}kumc.edu

Stem cells, irrespective of their origin, have emerged as valuable reagents or tools in human health in the past 2 decades. Initially, a research tool to study fundamental aspects of developmental biology is now the central focus of generating transgenic animals, drug discovery, and regenerative medicine to address degenerative diseases of multiple organ systems. This is because stem cells are pluripotent or multipotent cells that can recapitulate developmental paths to repair damaged tissues. However, it is becoming clear that stem cell therapy alone may not be adequate to reverse tissue and organ damage in degenerative diseases. Existing small-molecule drugs and biologicals may be needed as "molecular adjuvants" or enhancers of stem cells administered in therapy or adult stem cells in the diseased tissues. Hence, a combination of stem cell-based, high-throughput screening and 3D tissue engineering approaches is necessary to advance the next wave of tools in preclinical drug discovery. In this review, the authors have attempted to provide a basic account of various stem cells types, as well as their biology and signaling, in the context of research in regenerative medicine. An attempt is made to link stem cells as reagents, pharmacology, and tissue engineering as converging fields of research for the next decade. (Journal of Biomolecular Screening 2009:755-768)

Key Words: stem cells • iPS cells • drug discovery • 3D screening • tissue engineering • regenerative medicine

This version was published on August 1, 2009

Journal of Biomolecular Screening, Vol. 14, No. 7, 755-768 (2009)
DOI: 10.1177/1087057109336591
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