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Journal of Biomolecular Screening
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Compound Management Beyond Efficiency

Ian Burr

Exploratory Medicinal Science, Pfizer Global Research and Development, Sandwich, United Kingdom

Toby Winchester

Exploratory Medicinal Science, Pfizer Global Research and Development, Sandwich, United Kingdom

Wilma Keighley

Exploratory Medicinal Science, Pfizer Global Research and Development, Sandwich, United Kingdom

Andreas Sewing

Exploratory Medicinal Science, Pfizer Global Research and Development, Sandwich, United Kingdom, andreas.sewing{at}pfizer.com

Codeveloping alongside chemistry and in vitro screening, compound management was one of the first areas in research recognizing the need for efficient processes and workflows. Material management groups have centralized, automated, miniaturized and, importantly, found out what not to do with compounds. While driving down cost and improving quality in storage and processing, researchers still face the challenge of interfacing optimally with changing business processes, in screening groups, and with external vendors and focusing on biologicals in many companies. Here we review our strategy to provide a seamless link between compound acquisition and screening operations and the impact of material management on quality of the downstream processes. Although this is driven in part by new technologies and improved quality control within material management, redefining team structures and roles also drives job satisfaction and motivation in our teams with a subsequent positive impact on cycle times and customer feedback.

Key Words: material management • compound management • research • lead optimization

This version was published on June 1, 2009

Journal of Biomolecular Screening, Vol. 14, No. 5, 485-491 (2009)
DOI: 10.1177/1087057109333978
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