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Best Practices in Compound Management for Preserving Compound Integrity and Accurately Providing Samples for Assays

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut, sandra.matson{at}bms.com

Moneesh Chatterjee

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

David A. Stock

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

John E. Leet

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

Elizabeth A. Dumas

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

Christian D. Ferrante

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

William E. Monahan

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

Lynda S. Cook

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

John Watson

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

Normand J. Cloutier

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

Meredith A. Ferrante

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

John G. Houston

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

Martyn N. Banks

Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut

Preserving the integrity of the compound collection and providing high-quality materials for drug discovery in an efficient and cost-effective manner are 2 major challenges faced by compound management (CM) at Bristol-Myers Squibb (BMS). The demands on CM include delivering hundreds of thousands of compounds a year to a variety of operations. These operations range from single-compound requests to hit identification support and just-in-time assay plate provision for lead optimization. Support needs for these processes consist of the ability to rapidly provide compounds as solids or solutions in a variety of formats, establishing proper long- and short-term storage conditions and creating appropriate methods for handling concentrated, potent compounds for delivery to sensitive biological assays. A series of experiments evaluating the effects of processing compounds with volatile solvents, storage conditions that can induce freeze/thaw cycles, and the delivery of compounds were performed. This article presents the results of these experiments and how they affect compound integrity and the accuracy of compound management processes. (Journal of Biomolecular Screening 2009:476-484)

Key Words: compound management • drug discovery • storage conditions • sample distribution • volatile solvent transfer • hit identification • lead optimization

This version was published on June 1, 2009

Journal of Biomolecular Screening, Vol. 14, No. 5, 476-484 (2009)
DOI: 10.1177/1087057109336593


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