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A Method with Flexible and Balanced Control of False Negatives and False Positives for Hit Selection in RNA Interference High-Throughput Screening Assays: A Statistical Terminology

Department of Industrial Engineering and Management, Ben Gurion University, Beer Sheva, Israel, ednas{at}bgumail.bgu.ac.il

Zhang suggests a new method that is flexible and controls the balance between false negatives and false positives for hit selection in RNA high-throughput screening assays. The author shows that the same decision rules and balances can be expressed by familiar statistical terms such as type I error and power and hence connects the new method to known statistical tools. (Journal of Biomolecular Screening 2008:309-311)

Key Words: strictly standardized mean difference • restricted false-positive rate • high-throughput screening • hit selection

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