Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biomolecular Screening
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1087057106287139v1
11/4/435    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Hong, Y.
Right arrow Articles by Salon, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hong, Y.
Right arrow Articles by Salon, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

G-Protein-Coupled Receptor Microarrays for Multiplexed Compound Screening

Yulong Hong

Corning Incorporated, Corning, NY

Brian L. Webb

Corning Incorporated, Corning, NY

Sadashiva Pai

Corning Incorporated, Corning, NY

Ann Ferrie

Corning Incorporated, Corning, NY

Jinlin Peng

Corning Incorporated, Corning, NY

Fang Lai

Corning Incorporated, Corning, NY

Joydeep Lahiri

Corning Incorporated, Corning, NY

Gloria Biddlecome

Amgen Incorporated, Thousand Oaks, CA

Brian Rasnow

Amgen Incorporated, Thousand Oaks, CA

Michael Johnson

Amgen Incorporated, Thousand Oaks, CA

Hosung Min

Amgen Incorporated, Thousand Oaks, CA

Ye Fang

Corning Incorporated, Corning, NY

John Salon

Amgen Incorporated, Thousand Oaks, CA

Conventional assay methods for discovering and profiling drug-target interactions are typically developed on a target-by-target basis and hence can be cumbersome to enable and orchestrate. Herein the authors report a solid-state ligand-binding assay that operates in a multiplexed mode to report compound activity against a micorarray-configured panel of G-protein-coupled receptor (GPCR) targets. The pharmacological fidelity of the system is high, and its miniaturized "plug-and-play" format provides improved efficiency both in terms of execution time and reagent consumption. Taken together, these features make the system ideally suited to explore the structure-activity relationship of compounds across a broad region of target class space.

Key Words: GPCR • array • binding assay • fluorescent • HTS

This version was published on June 1, 2006

Journal of Biomolecular Screening, Vol. 11, No. 4, 435-438 (2006)
DOI: 10.1177/1087057106287139
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?